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It was a safety and pharmacokinetic study in 42 healthy volunteers, started in 2015, with results submission cancelled in 2016
Constipation tends to worsen with dose titration and stabilize after several weeks at a maintenance dose
The removal triggered a wind-down period during which compounding pharmacies could continue to produce tirzepatide for existing patients but were required to cease new compounding after the period ended
The solution should appear clear, without any visible particles
Pooled randomized trials through 2024 report mean weight reductions around 1.1 kilograms and similar fatmass reductions compared with placebo