The once-weekly injectable was originally used to help manage diabetes but gained FDA approval in 2021 for "chronic weight management." It suppresses appetite by balancing out the body's hunger hormones and delaying digestion, and has been shown to lead to a 15% to 20% loss of body weight over 68 weeks, Insider's Gabby Landsverk previously reported
The trade-off is doubled cost, doubled injection complexity, and IGF-1 elevation that can move into supraphysiological territory faster than either peptide alone
Hyaluronic acid is a gentle humectant that adds moisture without irritating the skin
Because availability and regulatory status can shift, it is imperative that medical directors and practitioners partner with highly reputable, compliant pharmacy partners
According to a narrative review done in 2025, it was originally isolated from human gastric juice by Dr
Nazitto R, Amon LM, Mast FD, Aitchison JD, Aderem A, Johnson JS, et al