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AARS1 binds directly to lactate, catalyzes the adenosine triphosphate (ATP)-dependent synthesis of lactate-AMP and mediates widespread lysine lactylation, including that of p53
Distinct Metabolic Roles of B12 vs
This magnitude of weight loss narrows the gap with bariatric procedures, although it remains below the average 25%-35% weight loss typically reported after sleeve gastrectomy or Roux-en-Y gastric bypass [6] , reinforcing the therapeutic potential of dual-pathway targeting
The most common baseline comorbidities were hypertension (94.6%) and hypercholesterolemia (88.9%), and common cardiovascular comorbidities included coronary heart disease (43.8%) and congestive heart failure (CHF
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