One randomized study found sunflower seed oil preserved skin barrier integrity in adult volunteers with and without atopic dermatitis (outperforming olive oil)
Stabilized NRF2 transcriptionally upregulates SLC7A11, restoring cystine uptake and GSH synthesis, thereby conferring ferroptosis resistance and directly counteracting sorafenibs mechanism of action
American Academy of Clinical Toxicology (February 2013), "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation , American College of Medical Toxicology and American Academy of Clinical Toxicology, retrieved 5 December 2013 David Rakel, Integrative Medicine 5th edition, Elsevier, 2023
Yi et al., 2014)
Mechanistically, Hedgehog binding to the transmembrane protein patched (PTC) induces the activation of smoothened (SMO), which stimulates the expression of downstream genes such as Ccnd1 via zinc finger transcription (GLI) factors
And that's exactly why a 2025 systematic review matters