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First, it highlights the unique role of COFs in reversing the immunosuppressive tumor microenvironment-through intrinsic enzyme-mimicking activities (such as catalase-like or glutathione peroxidase-like functions) or by carrying functional components-to alleviate hypoxia and deplete GSH (Section 5)

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For instance, certain pH- or redox-responsive materials may prematurely activate in the bloodstream, preventing effective drug release at the target site

Figure 4A shows the Eab* of all samples without supplementation with laccase and the corresponding sample with only the addition of sulfur dioxide