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Bionanoscience 8 , 196206 (2018)

Setmelanotide, while mechanistically rational, lacks confirmatory trial data specifically for MC4R -deficient obesity and should be regarded as an exploratory option at present

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doi: 10.1542/peds.2017-1811 91 FranzCMHuchMAbriouelHHolzapfelWGlvezA

Proteomic, metabolomic, and genetic analyses indicate altered small molecule transport underpinning this sweetenerdrug synergy