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Weight gain only creates more inflammation and leads to further depression

Similarly, GLP-1RAs exhibit pleiotropic benefits, including enhanced insulin secretion, reduced glucagon release, delayed gastric emptying, and appetite suppression, leading to significant weight loss and glycemic control 9

Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway

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The risk of bias in randomized controlled studies was assessed using the Cochrane Risk of Bias (RoB2) tool, while the ROBINS-I tool was employed for non-randomized studies included in this review

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