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Practically, the PCOS-specific trials measuring this fasting insulin, HOMA-IR scores, postprandial glucose responses, before and after NAC supplementation are smaller and more variable than the trial body behind inositol, vitamin D, or metformin

References Vaneev A, Tikhomirova V, Chesnokova N, Popova E, Beznos O, Kost O, et al

This results from a tyramine-induced depletion of norepinephrine normally present in the readily releasable vesicle pool, and replacement of vesicular norepinephrine with tyramine (which functions as a false- or pseudo- neurotransmitter), which when released has no effect on postsynaptic adrenergic receptors (Figure 1)