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Uses a tri-peptide glutathione to safely deliver a high dose of glutathione

In case of overdose, the sulphate and glucuronide pathways become saturated, and more paracetamol is shunted to CYP450 system to produce NAPQI

Serotonin also plays a role in the CNS and controls many stress mechanisms such as the HPA axis through stimulation of corticotropin-releasing hormone (CRH) (432)

Patients then gradually increase the dosage to 0.5 mg, then 1 mg, then 1.7 mg up to 2.4 mg at the highest dosage

Subsequently, peripheral axons die back as the neuronal mitochondria are unable to meet their metabolic requirements

Bradnam LV, Frasca J, Kimberley TJ