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However, the available evidence remains limited due to a lack of adequately powered randomized controlled trials specifically targeting CHE, heterogeneity in study designs, and regional differences in the formulations used

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Dex could exert a peripheral analgesic effect (produced by inhibiting the transmission of pain signals by inhibiting A and C fibers) and local analgesic effect (modulation of hyperalgesia by stimulating the 2 receptor) [23]