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NK cells NK cells are innate cytotoxic lymphocytes that surveil and eliminate tumor cells through the release of cytolytic granules (116)

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Herein, using in vitro TNBC models including cell lines with GPX4 or PC suppressed, together with murine models of obesity and TNBC growth and metastasis, we aimed to characterize (i) interactions between GPX4, PC, and lipid oxidative stress in TNBC cells, and (ii) the effect of GPX4 suppression, alone or in combination with chemotherapy or immunotherapy, on TNBC progression

If nausea or other GI side effects persist beyond 4-6 weeks despite dose stabilization, provider guidance should address whether to continue, adjust the formulation, or transition to an alternative

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