Moreover, as the negative effects of DMSO on the cell membrane are well known [1,2,3,15], in parallel to studies involving the direct addition of DMSO to the culture medium, a second method of administration was usedthe partial insertion of DMSO into polymerosomes (poly(ethylene glycol) and poly(lactide-co-glycolide) methyl ether block, PEG-PLGA) aimed at eliminating these potentially destructive effects
Therefore, some studies have attempted to embed icariin-containing nanogels in poloxamer to develop an icariin nanogel self-assembled thermosensitive hydrogel system, which adheres to the nasal mucosa and prolongs drug release time, thereby improving its bioavailability
A classic example is HMGB1 inducing Th1 cell differentiation through the TLR4 pathway, thereby enhancing antitumor immune effects (Tang et al., 2010) (154)
Karantanis D, Bogsrud TV, Wiseman GA, Mullan BP, Subramaniam RM, Nathan MA, Peller PJ, Bahn RS, Lowe VJ
Controlled attenuation parameter and alcoholic hepatic steatosis: diagnostic accuracy and role of alcohol detoxification
Zufira et al., 2016
