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The equivalent residue is a serine or alanine in oxyntomodulin and GLP-1 respectively, contributing to a more stable -helical conformation, while also forming additional interactions at the base of the GLP-1R binding pocket (Figs

212 Further, increased expression and low methylation of CDKN1A and PDE7B genes in T2DM can lead to impaired insulin release that is stimulated by glucose in T2DM patients