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These therapeutic differences may reflect distinct metabolic profiles and could act as confounders, as some antidiabetic agents might indirectly affect ocular surface homeostasis through hydration status or inflammatory pathways

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By delivering therapeutic agents like siRNA that targets IB, MnNPs can effectively trigger the NF-B signaling pathway in these macrophages, repolarizing them from a tumor-promoting M2 phenotype to a tumor-fighting M1 phenotype

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