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If it was exposed to heat during shipping or storage, or if it is well past its expiration date, the lyophilized powder may have undergone chemical changes that prevent proper dissolution

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Promote proliferation and differentiation of osteoblasts, accelerate bone formation Activate key signaling pathways in osteoblasts Wnt/ - catenin pathway: AOD 9604 upregulates Wnt3a expression, activates - catenin nuclear translocation, promotes osteoblast proliferation and differentiation, and enhances osteoblast quantity and activity

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1:200, rho=0.12, p = 0.603) (Fig