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In fact, the Cu 2+ -histidine interaction (binding) in nature can match the importance of iron (Fe 2+ ) binding with proteins, and the consequent haem interactions that support the very existence of life (Walton et al., 2023)

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And so it's like really cold in the morning is better and then kind of sort of cold in the evening is better

A single-atom manganese nanozyme Mn-N/C promotes anti-tumor immune response via eliciting type I interferon signaling

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PMC 4189588