46 Finally, Klonoff et al, using the Arcadia patient registry, also found no significant increase in NAION risk in patients taking semaglutide
Glucose metabolism mainly includes three types of pathways: glucose, which is first transported into the cell through glucose transporter 1 (GLUT1), then broken down by sequential metabolic enzymes, including hexokinase (HK), aldolase, phosphoglycerate kinase 1 (PGK1), and pyruvate kinase, to generate pyruvate, undergoes glycolysis in the cytoplasm to produce lactic acid under oxygen-deficient conditions
doi: 10.1016/j.ejogrb.2023.12.038 40
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IGF-1/IGF-1R induces differentiation rather than proliferation when the cells do not express or underexpress insulin receptor substrate-1 (IRS-1), a docking protein for both IGF-1R and the insulin receptor that is known to send a mitogenic, anti-apoptotic and anti-differentiation signal 35,36
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