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doi: 10.3389/fphar.2025.1528295 Received 14 November 2024 Accepted 28 February 2025 Published 25 March 2025 Volume 16 - 2025 Edited by Manuela Oliverio, Magna Grcia University, Italy Reviewed by Frederic Boal, Metabolic and Cardiovascular Research Institute, France Ren-Lei Ji, Harvard Medical School, United States Updates Copyright 2025 Al-Zaid and Al-Sabah

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However, if TSH rises during GLP-1 therapy, it may indicate your thyroid dose needs adjustment, not GLP-1 failure

Conclusion arGLP-1 are effective and safe for managing IWL or WR after BS, leading to significant weight loss, comorbidity improvement, and sustained %TWL

Bottom line: While you might feel the medications effects diminish slightly after five days, sticking to the seven-day schedule is the only way to ensure the medication stays at a safe, steady level in your system

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