Subgroup analysis of those subjects having reduced corneal nerve fibers, and therefore more definitive evidence of small fiber neuropathy (37), show that ARA 290 treatment is associated with an increase in corneal nerve fiber density, analogous to the improvement seen after improved metabolic control (42) and after simultaneous pancreas and kidney transplantation (43)
Mice injected with vehicle controls (saline or corn oil) or drug were treated with 0 Gy or 15 Gy within 1530 min of injection
Immunity 50 , 12621275.e4 (2019)
The Verdict This is not really an either/or decision
For individuals with conditions like pernicious anaemia, an autoimmune disorder that attacks the protein needed to absorb B12, oral supplements are often completely ineffective
A recent systematic review has documented this complementarity (McGuire et al., Curr Rev Musculoskelet Med 2025)