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Muscle loss is a significant concern, given tirzepatide's better lean mass preservation data

This effect is achieved by reducing the expression of Trem2 and NFATc1 and downregulating the expression of CTSK and TRAP to inhibit bone resorption activity

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Semaglutide has been making headlines in the medical community lately, and its easy to see why

This is especially important to consider for those with allergies or intolerances to ingredients such as lactose or gluten

Additionally, small, frequent meals are recommended, along with avoiding alcohol.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Nutritional considerations on a GLP-1 RA: Nutrition researchers from Harvard recommend the following while on a GLP-1:[ref] Protein: Aim for 1 1.5g/kg of body weight in order to maintain muscle mass while on a GLP-1 RA