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Patients who experience significant GI side effects may need to delay dose escalation

The column was Waters XBridge C8 column and gradient was from 20-90% MeCN/0.1% formic acid over 12 min

Bipolar disorder: A landmark RCT (n=75) found that NAC (1,000 mg twice daily for 24 weeks) produced a significant improvement in depression scores (Montgomery-Asberg Depression Rating Scale) in bipolar disorder as an adjunct to usual treatment (Berk et al., Biol Psychiatry, 2008) [74]

Quick Reference: Loading + Maintenance These figures reflect community-reported protocols, not a recommended schedule

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