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The copper(II) ion is essential for its activity and enables it to modulate copper-dependent enzymes in addition to its gene regulatory effects

Melatonin is truly a pleiotropic hormone: beyond circadian rhythm regulation and sleep, it has notable antioxidant, immunological, and neuroprotective effects all of which have implications for age-related degeneration

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[5] Protein [edit] GLUD1 is a hexamer