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In the post hoc analysis of MACE by prior HF in LEADER, there were 142 and 170 (with prior HF), and 466 and 524 (without prior HF) events with liraglutide and placebo, respectively.39 The interaction P value suggested no effect of prior HF status on the treatment effect on MACE ( P = 0.528).39 When considering HF as an endpoint in its own right, no effect of liraglutide, semaglutide (s.c

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N Engl J Med 2008;358:580-91 3