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As shown in Figure 13, palmatine was docked into the PAS site of AChE (PDB ID = 4EY7) through hydrogen bonding, van der Waals interaction, PI donor hydrogen bonding, Pi-Pi Stacked, and Pi-Pi T-shaped, based on the molecular docking studies, more rational design and structural modification can be performed on the palmatine in the future research, thus enhancing its anti-AD effect

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It slows intestinal motility and increases water reabsorption in the colon

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Then the function is said to be (i) If f'(x) is strictly increasing on I, then the function is concave up on the open interval I

Burruss NC, et al