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Retatrutide is also a larger, more complex molecule, roughly 4,731 daltons, a triple agonist with an albumin-binding tail, which is harder to synthesize cleanly and therefore more prone to carrying impurities when made cheaply for an unregulated market

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G6PD catalyzes the rate-limiting step of the PPP, effectively diverting G6P away from glycolysis toward 6-phosphogluconate, thereby promoting NADPH generation and glutathione synthesis ( Figure 6B )