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These large-scale studies, involving thousands of participants, did not report increased rates of colitis compared to placebo groups, though it's important to note that clinical trials may not detect rare adverse events due to sample size limitations

Rae CD, Baur JA, Borges K, Dienel G, Daz-Garca CM, Douglass SR, Drew K, Duarte JMN, Duran J, Kann O, Kristian T, Lee-Liu D, Lindquist BE, McNay EC, Robinson MB, Rothman DL, Rowlands BD, Ryan TA, Scafidi J, Scafidi S, Shuttleworth CW, Swanson RA, Uruk G, Vardjan N, Zorec R, McKenna MC (2024) Brain energy metabolism: a roadmap for future research

Dosing applicator a dosing format intended for research use, enabling standardised dispensing of the reagent within laboratory procedures (RUO)

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however, their mechanism is unlike other G-coupled protein receptors

Vigneri PG, Tirro E, Pennisi MS, Massimino M, Stella S, Romano C, et al