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Adjustments should be data-driven

Although microbiome modulation improves peripheral insulin sensitivity and reduces inflammatory burden, evidence for restoration of central insulin and leptin sensitivity remains limited

Most studies were judged to have a low risk of bias, but a few studies however showed moderate risk of bias

Arisi M, Rossi M, Rovati C, et al

Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency

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