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Dosage gradually increases over the initial weeks to minimize side effects and optimize effectiveness

The strip starts dissolving the moment it touches the tissue under your tongue

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(10 g or 10 ng/kg/day), topical (1.0 g in cream), or per-oral (0.16 g/mL in drinking water) over 90 days and described directional improvements across biomechanical, functional, macroscopic, and histological endpoints, though specific effect sizes and p-values are not reported in the abstract

A 2021 retrospective report described 16 people treated for knee pain