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This is partly because trunk fat is more metabolically active and responds more readily to the hormonal changes induced by GLP-1 therapy

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Intracerebroventricular KYNA infusions similarly impair conditioned orienting to visual cues, highlighting its role in disrupting attentional processing and implicating glia-derived KYNA in cognitive deficits relevant to neuropsychiatric and neurodegenerative disorders [76]