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Furthermore, peptides are susceptible to pH-mediated hydrolysis in the gastrointestinal tract, enzymatic degradation in the liver (CYP enzymes), and rapid renal clearance [156,157]
P171: Durable efficacy and safety of DTX301: Long-term follow up of a phase 1/2 trial in adults with ornithine transcarbamylase deficiency
It has been reported that the molecules on cell surface are not affected by collagenase D (Autengruber et al
24 More potent ferroptosis inhibitors may also protect due to off-target effects
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