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The most common side effects are gastrointestinal: nausea, diarrhoea, and decreased appetite (affecting more than 1 in 10 people)

doi:10.23736/S2724-6507.20.03369-6 16

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Ongoing clinical trials are evaluating the utility of GLP-1RAs as adjuncts in RA therapy, with particular focus on overweight patient populations [372]

A patient beginning compounded semaglutide might notice their resting heart rate increase by 3 to 5 beats per minute during weeks 1 through 4, then stabilize as their body adapts