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Chondrocytes, the only cellular component of cartilage, maintain the dynamic equilibrium of the extracellular matrix (ECM) through precise regulation of collagen type II and matrix-degrading enzyme secretion ( In mouse models of OA, typical characteristics of ferroptosis have been observed in chondrocytes, including abnormal iron metabolism, lipid peroxidation, and mitochondrial dysfunction (Sun et al., 2021)

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Mohana et al

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PLoS ONE 7 , e44679 (2012)