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There is evidence to suggest that PPA are formed in healthy individuals at therapeutic doses, particularly following repeated doses, suggesting that not all NAPQI is scavenged by glutathione even during therapeutic administration (see Fig
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Haile, C
20 Ubiquitin harbors eight sites available for ubiquitination, including seven internal lysine (Lys, K) residues (K6, K11, K27, K29, K33, K48, and K63) and the -amino group of the N-terminal methionine (M1), which contribute to the formation of distinct homotypic polyubiquitin chains and their unique topologies
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