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Armed with these findings, in March 1962 Marks proposed to a conference held in London at the Royal College of Physicians, that glucagon activated the secretion of insulin in B-cells of the pancreas

GLP-1 receptor agonists (colloquially known as GLP-1s) are medications that mimic this hormone

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Side effects may briefly return after dose increases but typically become milder with each adjustment

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References Harrington, D.D., & E.H