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Higher doses, longer treatment, and the presence of musculoskeletal pain before treatment began were also associated with greater lean body mass decline with both drugs, the researchers found

1,20 When used in conjunction with sulfonylureas or insulin, it may be necessary to adjust the dosage of the existing therapy to prevent hypoglycemia

Overall, PIONEER 5 provides some evidence that oral semaglutide may be an effective treatment option in patients with moderate renal impairment

Cancer Res 83:595612