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The company said no plateau was observed after patients transitioned to monthly dosing, which suggests that continued weight loss is expected as the study continues through week 64

This hypothesis is in line with a previous study showing the absence of cntA expression in human fecal samples (Rath et al., 2018) or with another investigation that demonstrated poor correlation between cntA abundance and TMAO plasma levels (Wu et al., 2019)

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Matsuoka K, Nishiumi S, Yoshida M, Kodama Y

However, semaglutide isn't suited for individuals with a personal or familial thyroid cancer history, multiple endocrine neoplasia syndrome type 2, or those with pancreatitis or severe gastrointestinal disorders

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