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Animal studies have shown that GLP-1 receptor agonists can promote thyroid C-cell tumors, and while human data remains limited, the FDA requires a black-box warning for this risk class

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Regarding macrovascular complications, comparable incidence of myocardial infarction was observed between patients receiving SGLT2i and GLP1-RA, which was consistent with a population-based cohort study [37]

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[58] [59] For those with elevated levels of PSA, TRUS guided biopsy is performed to take a sample of the prostate for investigation