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[7] The relevance of these animal findings to human patients remains uncertain and is the subject of ongoing pharmacovigilance

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For example, treatment with a vitamin D receptor agonist in zebrafish has been shown to induce the expression cell cycle genes such as cyclin s, cdk s, e2f s 52 , while activation of the vitamin D pathway in certain mammalian cancer cells led to upregulation of cell cycle inhibitors p27 and p21, as well as downregulation of cyclin D1 and cyclin D3 54

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