The condition is more prevalent during the winter since the low humidity of the air dries the skin, and it usually improves or clears during the summer due to the higher humidity
For example, recent findings indicate that HSPA1B facilitates the exosomal secretion of metalloproteinases from macrophages, thereby helping to mitigate fibrosis (Xiao et al., 2025)
In depressed patients, the expression and availability of glucocorticoid receptors are decreased, which prevents the HPA axis from exerting anti-inflammatory effects and promotes persistent inflammation (94, 95)
While an intramuscular injection into the healthy part of the bicep muscle belly is possible, its often unnecessary
Avoid eating or drinking anything after midnight, including water, to prevent nausea during the procedure
Sextius P, Betts R, Benkhalifa I, Commo S, Eilstein J, Massironi M