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2018;61(Suppl 1):S346 [Abstract 714]

The dual mechanism is why Eli Lilly positions tirzepatide as a distinct therapeutic option and why some patients specifically need it rather than a single-agonist alternative

The STEP trials evaluated higher-dose semaglutide (2.4 mg weekly) for weight management

Reference Tirzepatides Therapeutic Spectrum: Dual GIP/GLP-1 PMC 2025 Real-World Tirzepatide vs Semaglutide PMC 2025 Tirzepatide Improves Beta-Cell Function PMC When Insulin is Needed & Types of Insulin For many Indian patients, the word insulin brings fear

In case of unsatisfactory clinical response, the dose can be increased to 1000g [447-449]