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All authors have seen and approved the content, and contributed significantly to the work

While sterile water has no preservative, the BAC diluent includes benzyl alcohol

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The search was conducted using the following search pattern: Acetylcysteine [Mesh] OR acetylcysteine [tiab] OR nacetylcysteine [tiab] OR n-acetyl cysteine [tiab]) OR NAC [tiab] AND ovulation [Mesh] OR total testosterone [tiab] OR progesterone [tiab] OR sexual function [tiab] OR impotence/erectile/dysfunction [tiab] OR sex hormone-binding globulin (SHBG) [tiab] AND Polycystic Ovary Syndrome [tiab] OR Ovary Syndrome [tiab] OR Polycystic Syndrome [tiab] OR Polycystic Ovary [tiab] OR Polycystic ovary disease [tiab] OR Stein-Leventhal Syndrome [tiab] OR Stein Leventhal Syndrome [tiab] OR Syndrome, Stein-Leventhal [tiab] OR Sclerocystic Ovarian Degeneration [tiab] OR Ovarian Degeneration, Sclerocystic [tiab]

Using a similar process, the risk of bias for intervention trials included in the review omitting the case report [54] was assessed using the criteria set out in the Cochrane Collaboration Handbook [55]