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Additional file 3 (download DOCX : Patient attrition flow chart
Lipotoxicity is the effect of abnormal lipid metabolism on islet cells
It non-selectively mimics the action of melanocortin peptides
This will be subject to clinical review
1 When diabetic patients are not at risk of DKA, basal insulin plus noninsulin hypoglycemic agents with weight loss effects are recommended for those with preobesity/obesity or without weight loss, and basal insulin/premix insulin plus secretagogues or DPP-4i are recommended for those without preobesity/obesity and with weight loss concerns
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