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Taking a massive single dose of 3 grams will not result in a proportionate increase in blood plasma levels

Ramrez-Maldonado M, Jurado-Fasoli L, del Coso J, Ruiz R, Amaro-Gahete J FJ (2021) Caffeine increases maximal fat oxidation during a graded exercise test: is there a diurnal variation

Basically, when this reaction starts, it creates heat

For othersespecially those with higher demands, specific medications, metabolic issues, or aggressive weight-management planssupplementing into a higher, therapeutic range can make sense

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