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It also supports nerve regeneration and reduces oxidative stress two mechanisms thought to underlie its benefits for diabetic neuropathy.48 Randomized trials have shown that taking 1,0002,000mg of ALCAR daily may help reduce pain, improve vibration perception, and enhance nerve conduction in people with diabetic neuropathy especially when treatment begins early.49 Vibration perception refers to the ability to sense low-frequency vibrations, such as those from tuning forks a key part of nerve function often tested in clinical exams to assess sensory loss in the feet and legs

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doi: 10.1111/exd.13986 50

Yes, Jennifer Aniston and many other celebrities have publicly shared their use of NAD+ therapy as part of their wellness routine

However, human safety data beyond 12 weeks doesn't exist