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When activated, a receptor triggers physiological reactions such as membrane phospholipid hydrolysis, intracellular calcium mobilization, and phosphorylation of vital intracellular proteins
Mediated through PKA, CaMKII, and Na + /Ca 2+ exchanger signaling pathways, GLP-1RAs reduce pulmonary vein automaticity and arrhythmogenesis, ultimately suppressing atrial fibrillation initiation
NE from sympathetic nerves passes into the intestinal lumen We used a Ussing chamber to investigate whether the NE concentration on the mucosal side of the cecal tissue was increased by administration of drugs to the serosal side
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