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Activation of GLP-1R reduced NTG-induced c-fos expression in the TNC In addition to CGRP, we also detected alterations in c-fos expression in the TNC, which is a reliable marker of neuronal activation and is considered another mediator of central sensitization

Treatment with 3 mg liraglutide for 20 weeks reduced appetite and energy intake, resulting in a significant weight loss (7.2 kg) in a large, RCT in people with obesity [15]

However, additional studies would be necessary to validate these conclusions

Current evidence suggests that staying on a GLP-1 medication for at least 12-24 months after reaching your goal allows your brain's appetite-control circuits and eating habits to stabilize

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