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Phentermine alone carries a black-box warning for cardiovascular events when used beyond 12 weeks

Multimodal physical therapy programs that combine muscle training, education, and physical activity have also shown strong improvements in symptoms and quality of life, with high patient satisfaction and no reported safety concerns

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In the 2023 New England Journal of Medicine trial, the retatrutide treatment groups showed not only gastrointestinal abnormalities but also a dose-dependent increase in heart rate