1 Heres what the 40-week results showed: HbA1c reductions: Tirzepatide 5 mg: reduced HbA1c by 2.01 percentage points Tirzepatide 10 mg: reduced HbA1c by 2.24 percentage points Tirzepatide 15 mg: reduced HbA1c by 2.30 percentage points Weight loss: Tirzepatide 5 mg: 7.6 kg (8.5% of body weight) Tirzepatide 10 mg: 9.3 kg (approximately 10% of body weight) Tirzepatide 15 mg: 11.2 kg (13.1% of body weight) Achieving target HbA1c: 92% of participants on 15 mg achieved HbA1c below 7% 51% achieved HbA1c below 5.7% (normal, non-diabetic range) These results were significantly better than semaglutide 1 mg (the comparison drug in the trial), where 81% achieved HbA1c below 7% and participants lost an average of 6.2 kg
And in my own primary care practice, Ive prescribed drugs in that same GLP-1 family since 2008, so we have extensive experience with these medications
Rebound Weight Gain If you stop taking semaglutide, its possible to gain some (or all) of the weight back
Is microdosing safe with compounded GLP-1 medications
As a result, semaglutide has found a new market as a slimming aid in people without type 2 diabetes, nicknamed the skinny jab
Semaglutide comparison for context Many researchers transition between tirzepatide and semaglutide , or use both sequentially
