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In serum, first-episode, antipsychotic-nave patients show reductions in TRP, KYN, KYNA, anthranilic acid, and modestly lower 3-HK and QA, indicating early KP dysregulation, and long-term antipsychotic treatment partially normalizes these metabolites [238]

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Cyclophosphamide, a nitrogen mustard, induces GPX4 degradation and activates AIFM1, leading to parthanatos in leukemia cells [155]

The upregulated expression of ZIP7 facilitates the proliferation and aggression of tamoxifen-resistant MCF-7 cells by activating epithelial growth factor receptor (EGFR), insulin-like growth factor receptor 1 (IGF1R), and tyrosine kinase Src

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Biomater Res