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Presently the combination of a non-bile acid FXR agonist (GS-9674) + ACC inhibitor (GS-0976) is being investigated in an early phase II clinical trial.103 In an animal model of NASH, treatment with this combination therapy demonstrated a greater reduction in hepatic steatosis and genes associated with fibrosis than treatment with either agent alone.104 Future clinical trials will likely use combinations of agents that have already produced positive results individually

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Finally, although our meta-analysis showed that GLP-1 receptor agonists increased the risk of overall thyroid disorder, due to the decrease in sample size, it did not show statistically significant results for specific thyroid disorder

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